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PROTO-ONCOGENE PROTEINS C-BCR
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DeCS
Descriptor
English
:
Proto-Oncogene Proteins c-bcr
Descriptor
Spanish
:
Proteínas Proto-Oncogénicas c-bcr
Descriptor
Portuguese
:
Proteínas Proto-Oncogênicas c-bcr
Synonyms
English
:
bcr Proto-Oncogene Proteins
c-bcr Proteins
Tree Number:
D08.811.913.696.620.682.700.759
D12.776.624.664.700.171
Definition
English
:
Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of
CELL PROLIFERATION
and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION
PROTEINS
in
PHILADELPHIA CHROMOSOME
positive
LEUKEMIA
patients.
History Note
English
:
2006(1988)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50725
Unique Identifier:
D051562
Occurrence in VHL
:
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CID-10
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